MCL-1 expression in B-cell non-Hodgkin's lymphomas
JH Cho-Vega, GZ Rassidakis, JH Admirand, M Oyarzo… - Human pathology, 2004 - Elsevier
B-cell non-Hodgkin's lymphomas are known to express BCL-2 family proteins, of which the
myeloid cell leukemia-1 (MCL-1) protein is a member. MCL-1 is involved in viability and
immortalization of normal and neoplastic B cells, and expression is regulated
transcriptionally and posttranscriptionally, resulting in an anti-apoptotic (full length) or a pro-
apoptotic (short isoform) gene product. In this study, we assessed 151 B-cell lymphomas for
MCL-1 expression and analyzed for expression of the full-length and short isoforms of MCL …
myeloid cell leukemia-1 (MCL-1) protein is a member. MCL-1 is involved in viability and
immortalization of normal and neoplastic B cells, and expression is regulated
transcriptionally and posttranscriptionally, resulting in an anti-apoptotic (full length) or a pro-
apoptotic (short isoform) gene product. In this study, we assessed 151 B-cell lymphomas for
MCL-1 expression and analyzed for expression of the full-length and short isoforms of MCL …
