A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis
AL Li, HY Li, BF Jin, QN Ye, T Zhou, XD Yu… - Journal of Biological …, 2004 - ASBMB
Although eukaryotic translation initiation factor 5A (eIF5A) was originally designated as an"
initiation factor," recent data have shown it to be also involved in apoptosis. However, the
actual function of eIF5A in apoptosis is still unknown. In this study, we performed yeast two-
hybrid screens to identify eIF5A-interacting proteins to help us understand the mechanisms
of eIF5A. Our results demonstrated that eIF5A and syntenin could engage in a specific
interaction both in vitro and in vivo and functioned collaboratively to regulate p53 activity …
initiation factor," recent data have shown it to be also involved in apoptosis. However, the
actual function of eIF5A in apoptosis is still unknown. In this study, we performed yeast two-
hybrid screens to identify eIF5A-interacting proteins to help us understand the mechanisms
of eIF5A. Our results demonstrated that eIF5A and syntenin could engage in a specific
interaction both in vitro and in vivo and functioned collaboratively to regulate p53 activity …
