Rexinoids modulate steroid and xenobiotic receptor activity by increasing its protein turnover in a calpain-dependent manner
F Pettersson, N Hanna, M Lagodich… - Journal of biological …, 2008 - ASBMB
The steroid and xenobiotic receptor SXR (human pregnane X receptor) is a nuclear receptor
that plays a key role in the body's detoxification response by regulating genes involved in
drug metabolism and transport. SXR ligands include a wide range of compounds, which
induce transcription of SXR target genes via activation of a heterodimeric transcription factor
consisting of SXR and the related nuclear receptor retinoid X receptor (RXR). We
investigated the effect of RXR-selective ligands, rexinoids, on SXR/RXR activity. In …
that plays a key role in the body's detoxification response by regulating genes involved in
drug metabolism and transport. SXR ligands include a wide range of compounds, which
induce transcription of SXR target genes via activation of a heterodimeric transcription factor
consisting of SXR and the related nuclear receptor retinoid X receptor (RXR). We
investigated the effect of RXR-selective ligands, rexinoids, on SXR/RXR activity. In …
