The identification of hydroxy fatty acids in psoriatic skin
RDR Camp, AI Mallet, PM Woollard, SD Brain… - Prostaglandins, 1983 - Elsevier
Psoriasis is a common chronic inflammatory and proliferative skin disease characterised by
epidermal neutrophil infiltration which may be induced by chemotactic substances in the
involved epidermis. Superficial psoriatic scale was shown to contain biologically active
amounts of leukotriene B 4 and monohydroxy-eicosatetraenoic acid (HETE)-like material as
determined by assay for chemokinetic activity in high performance liquid chromatography
(HPLC) fractions of scale extracts. Extracts of scale and chamber fluid from abraded lesional …
epidermal neutrophil infiltration which may be induced by chemotactic substances in the
involved epidermis. Superficial psoriatic scale was shown to contain biologically active
amounts of leukotriene B 4 and monohydroxy-eicosatetraenoic acid (HETE)-like material as
determined by assay for chemokinetic activity in high performance liquid chromatography
(HPLC) fractions of scale extracts. Extracts of scale and chamber fluid from abraded lesional …