Immature B cell malignancies synthesize VEGF, VEGFR-1 (Flt-1) and VEGFR-2 (KDR)
A El-Obeid, N Sunnuqrut, A Hussain, K Al-Hussein… - Leukemia research, 2004 - Elsevier
Expression of VEGF and VEGFR support a role for angiogenic pathways in the
pathogenesis of some hematological malignances. Our goal was to determine if expression
of these angiogenic molecules also extend to childhood precursor B cell acute
lymphoblastic leukemia (pre-B ALL). We now show that transcripts of VEGF, and its
receptors VEGFR-1 and VEGFR-2 are concomitantly expressed in both ALL cell lines and
primary pre-B ALL. Western blot and ELISA consistently detected VEGF protein in the …
pathogenesis of some hematological malignances. Our goal was to determine if expression
of these angiogenic molecules also extend to childhood precursor B cell acute
lymphoblastic leukemia (pre-B ALL). We now show that transcripts of VEGF, and its
receptors VEGFR-1 and VEGFR-2 are concomitantly expressed in both ALL cell lines and
primary pre-B ALL. Western blot and ELISA consistently detected VEGF protein in the …
