Esterifying lysophospholipids may serve a variety of functions, including phospholipid
remodeling and limiting the abundance of bioactive lipids. Recently, a yeast enzyme, Lpt1p,
that esterifies an array of lysophospholipids was identified. Described here is the
characterization of a human homolog of LPT1 that we have called lysophosphatidylcholine
acyltransferase 3 (LPCAT3). Expression of LPCAT3 in Sf9 insect cells conferred robust
esterification of lysophosphatidylcholine in vitro. Kinetic analysis found apparent …