Chaperone‐mediated autophagy in aging and disease
AC Massey, C Zhang, AM Cuervo - Current topics in developmental …, 2006 - Elsevier
Different mechanisms target intracellular components for their degradation into lysosomes
through what is known as autophagy. In mammals, three main forms of autophagy have
been described: macroautophagy, microautophagy, and chaperone‐mediated autophagy
(CMA). CMA is the only autophagic pathway that allows selective degradation of soluble
proteins in lysosomes. In contrast to the other mammalian forms of autophagy, CMA does
not require vesicle formation or major changes in the lysosomal membrane. Instead …
through what is known as autophagy. In mammals, three main forms of autophagy have
been described: macroautophagy, microautophagy, and chaperone‐mediated autophagy
(CMA). CMA is the only autophagic pathway that allows selective degradation of soluble
proteins in lysosomes. In contrast to the other mammalian forms of autophagy, CMA does
not require vesicle formation or major changes in the lysosomal membrane. Instead …
