The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction
CB Coyne, T Voelker, SL Pichla… - Journal of Biological …, 2004 - ASBMB
The coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial cell tight
junction. In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as
an interaction partner for the CAR cytoplasmic domain. CAR and MUPP1 were found to
colocalize at the tight junction, to coprecipitate from epithelial cells, and to interact in vitro.
The interaction was found to specifically involve the PDZ-binding motif within the CAR C
terminus and MUPP1 PDZ domain 13. In transfected cells, CAR recruited MUPP1 to cell-cell …
junction. In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as
an interaction partner for the CAR cytoplasmic domain. CAR and MUPP1 were found to
colocalize at the tight junction, to coprecipitate from epithelial cells, and to interact in vitro.
The interaction was found to specifically involve the PDZ-binding motif within the CAR C
terminus and MUPP1 PDZ domain 13. In transfected cells, CAR recruited MUPP1 to cell-cell …
