BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria
X Li, H Chen, JJ Jeong, AH Chishti - Molecular and biochemical …, 2007 - Elsevier
Falcipains, the papain-family cysteine proteases of the Plasmodium falciparum, are potential
drug targets for malaria parasite. Pharmacological inhibition of falcipains can block the
hydrolysis of hemoglobin, parasite development, and egress, suggesting that falcipains play
a key role at the blood stage of parasite life cycle. In the present study, we evaluated the anti-
malarial effects of BDA-410, a novel cysteine protease inhibitor as a potential anti-malarial
drug. Recombinant falcipain (MBP-FP-2B) and P. falciparum trophozoite extract containing …
drug targets for malaria parasite. Pharmacological inhibition of falcipains can block the
hydrolysis of hemoglobin, parasite development, and egress, suggesting that falcipains play
a key role at the blood stage of parasite life cycle. In the present study, we evaluated the anti-
malarial effects of BDA-410, a novel cysteine protease inhibitor as a potential anti-malarial
drug. Recombinant falcipain (MBP-FP-2B) and P. falciparum trophozoite extract containing …
