[HTML][HTML] Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130: I. Definition …
C Gerhartz, B Heesel, J Sasse, U Hemmann… - Journal of Biological …, 1996 - ASBMB
Interleukin-6 (IL-6) and γ-interferon (IFNγ) activate an overlapping set of genes via the
Jak/STAT pathway. However, at least in human cells, a differential activation of STAT
transcription factors was observed: IL-6 activates both acute phase response factor
(APRF)/STAT3 and STAT1, whereas IFNγ leads only to STAT1 activation. All STATs cloned
so far contain SH2 domains. Since all cytokine receptors using the Jak/STAT pathway were
found to be tyrosine-phosphorylated after ligand binding, it has been proposed that specific …
Jak/STAT pathway. However, at least in human cells, a differential activation of STAT
transcription factors was observed: IL-6 activates both acute phase response factor
(APRF)/STAT3 and STAT1, whereas IFNγ leads only to STAT1 activation. All STATs cloned
so far contain SH2 domains. Since all cytokine receptors using the Jak/STAT pathway were
found to be tyrosine-phosphorylated after ligand binding, it has been proposed that specific …
