Apolipoprotein E and progression of chronic kidney disease
ContextApolipoprotein E (APOE) genetic variation has been implicated in diabetic
nephropathy with the ε2 allele increasing and the ε4 allele decreasing risk. APOE allelic
associations with chronic kidney disease beyond diabetic nephropathy are unknown, with
no studies reported in high-risk African American populations. ObjectiveTo quantify the risk
of chronic kidney disease progression associated with APOE in a population-based study
including white, African American, diabetic, and nondiabetic individuals. Design, Setting …
nephropathy with the ε2 allele increasing and the ε4 allele decreasing risk. APOE allelic
associations with chronic kidney disease beyond diabetic nephropathy are unknown, with
no studies reported in high-risk African American populations. ObjectiveTo quantify the risk
of chronic kidney disease progression associated with APOE in a population-based study
including white, African American, diabetic, and nondiabetic individuals. Design, Setting …
