Suppressors of cytokine signaling and immunity
M Kubo, T Hanada, A Yoshimura - Nature immunology, 2003 - nature.com
M Kubo, T Hanada, A Yoshimura
Nature immunology, 2003•nature.comThe suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key
physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T
cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here
we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with
particular emphasis on the relationship between immune regulation and SOCS.
physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T
cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here
we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with
particular emphasis on the relationship between immune regulation and SOCS.
Abstract
The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.
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