Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fcγ receptors
A Marcilla, OM Rivero-Lezcano, A Agarwal… - Journal of Biological …, 1995 - ASBMB
We have recently identified the protein product of the c-cbl proto-oncogene as an SH3
binding protein expressed in macrophages. To investigate the possibility that p120 c-cbl is
involved in signaling pathways initiated by cell surface receptors for IgG (FcγR), lysates of
HL60 cells were examined for tyrosine phosphorylation of p120 c-cbl upon FcγR
engagement. Our findings demonstrate that p120 c-cbl is tyrosine-phosphorylated upon
FcγR engagement and that this molecule represents the major tyrosine kinase substrate in …
binding protein expressed in macrophages. To investigate the possibility that p120 c-cbl is
involved in signaling pathways initiated by cell surface receptors for IgG (FcγR), lysates of
HL60 cells were examined for tyrosine phosphorylation of p120 c-cbl upon FcγR
engagement. Our findings demonstrate that p120 c-cbl is tyrosine-phosphorylated upon
FcγR engagement and that this molecule represents the major tyrosine kinase substrate in …
