[HTML][HTML] The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
W Lin, SL Bailey, H Ho, HP Harding… - The Journal of …, 2007 - Am Soc Clin Investig
The Journal of clinical investigation, 2007•Am Soc Clin Investig
The exact role (s) of the cytokine IFN-γ in the demyelinating disease multiple sclerosis
remain controversial, with evidence suggesting both detrimental and protective effects of the
cytokine in MS and MS models such as EAE. The study by Lin and coworkers in this issue of
the JCI produces evidence that protective effects of IFN-γ on mature oligodendrocytes during
EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in
induction of the endoplasmic reticular stress response pathway (see the related article …
remain controversial, with evidence suggesting both detrimental and protective effects of the
cytokine in MS and MS models such as EAE. The study by Lin and coworkers in this issue of
the JCI produces evidence that protective effects of IFN-γ on mature oligodendrocytes during
EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in
induction of the endoplasmic reticular stress response pathway (see the related article …
Abstract
The exact role (s) of the cytokine IFN-γ in the demyelinating disease multiple sclerosis remain controversial, with evidence suggesting both detrimental and protective effects of the cytokine in MS and MS models such as EAE. The study by Lin and coworkers in this issue of the JCI produces evidence that protective effects of IFN-γ on mature oligodendrocytes during EAE induction are mediated via activation of the pancreatic ER kinase (PERK), resulting in induction of the endoplasmic reticular stress response pathway (see the related article beginning on page 448). Modulation of this stress pathway has what we believe to be novel therapeutic potential for MS.
The Journal of Clinical Investigation