The normal prostate shows a high degree of cellular organization. The basal layer is
populated by prostate epithelial stem cells and a population of transiently
proliferating/amplifying (TP/A) cells intermediate to the stem cells and fully differentiated
cells. The luminal layer is composed of fully differentiated prostate epithelial cells.
Neuroendocrine cells are scattered throughout the gland. This organization is also seen in
prostate cancer, where the tumor cell origin (cancer stem cells) can be traced to a normal …