Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle
SV Ekholm, SI Reed - Current opinion in cell biology, 2000 - Elsevier
SV Ekholm, SI Reed
Current opinion in cell biology, 2000•ElsevierCyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian
cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G1 to S phase transition.
Because proper regulation of this transition is critical for an organism's survival, these
protein kinases are exquisitely regulated at different mechanistic levels and in response to a
large variety of intrinsic and extrinsic signals.
cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G1 to S phase transition.
Because proper regulation of this transition is critical for an organism's survival, these
protein kinases are exquisitely regulated at different mechanistic levels and in response to a
large variety of intrinsic and extrinsic signals.
Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G1 to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.
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