Cell-cycle checkpoint kinases: checking in on the cell cycle
NC Walworth - Current opinion in cell biology, 2000 - Elsevier
NC Walworth
Current opinion in cell biology, 2000•ElsevierIn response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA
repair. The idea that checkpoint controls are an integral component of normal cell-cycle
progression has arisen as a result of studies in Drosophila and mice. In addition, an
appreciation that DNA damage arises as a natural consequence of cellular metabolism,
including DNA replication itself, has influenced thinking regarding the nature of checkpoint
pathways.
repair. The idea that checkpoint controls are an integral component of normal cell-cycle
progression has arisen as a result of studies in Drosophila and mice. In addition, an
appreciation that DNA damage arises as a natural consequence of cellular metabolism,
including DNA replication itself, has influenced thinking regarding the nature of checkpoint
pathways.
In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.
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