[HTML][HTML] Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene (∗)
ML Norris, DE Millhorn - Journal of Biological Chemistry, 1995 - ASBMB
We reported recently that the gene that encodes tyrosine hydroxylase (TH), the rate-limiting
enzyme in the biosynthesis of catecholamines, is regulated by hypoxia in the dopaminergic
cells of the mammalian carotid body (Czyzyk-Krzeska, MF, Bayliss, DA, Lawson, EE &
Millhorn, DE (1992) J. Neurochem. 58, 1538-1546) and in pheochromocytoma (PC12) cells
(CzyzykKrzeska, MF, Furnari, BA, Lawson, EE & Millhorn, DE (1994) J. Biol. Chem. 269, 760-
764). Regulation of this gene during low O 2 conditions occurs at both the level of …
enzyme in the biosynthesis of catecholamines, is regulated by hypoxia in the dopaminergic
cells of the mammalian carotid body (Czyzyk-Krzeska, MF, Bayliss, DA, Lawson, EE &
Millhorn, DE (1992) J. Neurochem. 58, 1538-1546) and in pheochromocytoma (PC12) cells
(CzyzykKrzeska, MF, Furnari, BA, Lawson, EE & Millhorn, DE (1994) J. Biol. Chem. 269, 760-
764). Regulation of this gene during low O 2 conditions occurs at both the level of …
