The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells
K Freeland, LM Boxer, DS Latchman - Molecular brain research, 2001 - Elsevier
In neuronal cells, expression of the anti-apoptotic Bcl-2 gene is induced by hypoxia and
produces a protective effect. We show here that this effect is dependent upon the cyclic AMP
response element (CRE) in the Bcl-2 promoter since mutation of this element abolishes the
response and the isolated CRE can confer the response on a heterologous promoter.
Interestingly however, the CRE in the Bcl-2 promoter does not render the promoter
responsive to cyclic AMP and is not essential for its response to nerve growth factor. Despite …
produces a protective effect. We show here that this effect is dependent upon the cyclic AMP
response element (CRE) in the Bcl-2 promoter since mutation of this element abolishes the
response and the isolated CRE can confer the response on a heterologous promoter.
Interestingly however, the CRE in the Bcl-2 promoter does not render the promoter
responsive to cyclic AMP and is not essential for its response to nerve growth factor. Despite …
