Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons
NR Prabhakar, SF Pieramici, DRD Premkumar… - Molecular brain …, 1996 - Elsevier
In the present study we examined the effects of hypobaric hypoxia on neuronal (n) and
endothelial (e) nitric oxide synthase (NOS) gene expression in the central and peripheral
nervous system. Adult rats were exposed either to normoxia (room air) or to hypobaric
hypoxia (0.4 atm) for 4, 12 or 24 h and cerebellum and nodose ganglion representing the
central and peripheral neurons, respectively, were removed. Messenger RNAs encoding n-
and eNOS as well as β-actin were analyzed by reverse transcriptase polymerase chain …
endothelial (e) nitric oxide synthase (NOS) gene expression in the central and peripheral
nervous system. Adult rats were exposed either to normoxia (room air) or to hypobaric
hypoxia (0.4 atm) for 4, 12 or 24 h and cerebellum and nodose ganglion representing the
central and peripheral neurons, respectively, were removed. Messenger RNAs encoding n-
and eNOS as well as β-actin were analyzed by reverse transcriptase polymerase chain …
