[HTML][HTML] Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK …
B Zhang, J Hirahashi, X Cullere, TN Mayadas - Journal of Biological …, 2003 - ASBMB
Phagocytosis of complement-opsonized targets is a primary function of neutrophils at sites of
inflammation, and the clearance of neutrophils that have phagocytosed microbes is
important for the resolution of inflammation. Our previous work suggests that phagocytosis
leads to rapid neutrophil apoptosis that is inhibited by antibody to the β 2 integrin, Mac-1,
and requires NADPH oxidase-derived reactive oxygen species (ROS) generated during
phagocytosis. Here we report that phagocytosis-induced cell death (PICD) does not occur in …
inflammation, and the clearance of neutrophils that have phagocytosed microbes is
important for the resolution of inflammation. Our previous work suggests that phagocytosis
leads to rapid neutrophil apoptosis that is inhibited by antibody to the β 2 integrin, Mac-1,
and requires NADPH oxidase-derived reactive oxygen species (ROS) generated during
phagocytosis. Here we report that phagocytosis-induced cell death (PICD) does not occur in …