Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice
LP Shearman, KM Rosko, R Fleischer… - Behavioural …, 2003 - journals.lww.com
Psychopathological disorders, and depression in particular, are strongly linked to eating
attitude in obese patients. The identification of cannabinoid CB1 receptors (CB1Rs) in areas
of the central nervous system (CNS) that have been implicated in regulation of mood and
food intake suggests that these receptors may mediate such a behavioral link. The goal of
this study was to evaluate CB1R modulation of antidepressant-like effects and food intake.
For this purpose, 129/SVE and C57BL/6 male mice were acutely dosed intraperitoneally (ip) …
attitude in obese patients. The identification of cannabinoid CB1 receptors (CB1Rs) in areas
of the central nervous system (CNS) that have been implicated in regulation of mood and
food intake suggests that these receptors may mediate such a behavioral link. The goal of
this study was to evaluate CB1R modulation of antidepressant-like effects and food intake.
For this purpose, 129/SVE and C57BL/6 male mice were acutely dosed intraperitoneally (ip) …
