Expansion of an Unusual Population of Gr-1+ CD3intCells in the Lymph Nodes and Other Peripheral Organs of Mice Carrying thelprGene
S Honda, K Takeda, J Narita, T Koya, T Kawamura… - Cellular …, 1997 - Elsevier
Granulocytes and extrathymic T cells are often activated simultaneously, but they are
absolutely separate populations in normal mice. However, some abnormal extrathymic T
cells (ie, CD3intcells) seen in mice carrying thelprgene were found to express a granulocyte
marker, Gr-1. Such mice include MRL-lpr/lprmice and SCG mice. In parallel with an age-
associated increase of IL-2RβlowCD3intcells which contained double-negative CD4− 8−
and B220+ CD2− cells, Gr-1+ CD3intcells increased in number in the lymph nodes and …
absolutely separate populations in normal mice. However, some abnormal extrathymic T
cells (ie, CD3intcells) seen in mice carrying thelprgene were found to express a granulocyte
marker, Gr-1. Such mice include MRL-lpr/lprmice and SCG mice. In parallel with an age-
associated increase of IL-2RβlowCD3intcells which contained double-negative CD4− 8−
and B220+ CD2− cells, Gr-1+ CD3intcells increased in number in the lymph nodes and …
