[HTML][HTML] Effect of KRN7000 on induced graft-vs-host disease
S Morecki, S Panigrahi, G Pizov, E Yacovlev… - Experimental …, 2004 - Elsevier
OBJECTIVE: Graft-vs-host disease (GVHD) is a serious complication of allogeneic stem cell
transplantation (SCT) and donor lymphocyte infusion (DLI), for which no effective therapy
exists. In our study, KRN7000, a synthetic analog of α-galactosylceramide, known for its
ability to activate natural killer T cells, was tested for its ability to prevent onset of GVHD in a
murine model of haploidentical major histocompatible (MHC) mismatched hematopoietic
cells. METHODS: Irradiated (BALB/cXC57BL/6) F1 mice were inoculated with parental …
transplantation (SCT) and donor lymphocyte infusion (DLI), for which no effective therapy
exists. In our study, KRN7000, a synthetic analog of α-galactosylceramide, known for its
ability to activate natural killer T cells, was tested for its ability to prevent onset of GVHD in a
murine model of haploidentical major histocompatible (MHC) mismatched hematopoietic
cells. METHODS: Irradiated (BALB/cXC57BL/6) F1 mice were inoculated with parental …
