[HTML][HTML] Progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3 is a potent mobilizer of …
WH Fleming, JM Mulcahy, JP McKearn… - Experimental …, 2001 - Elsevier
OBJECTIVE: Progenipoietin-1 is an agonist of both the granulocyte colony-stimulating factor
and fetal liver tyrosine kinase-3 receptors capable of inducing the proliferation of multiple
hematopoietic cell lineages. The potential of progenipoietin-1 to mobilize transplantable
hematopoietic stem cells into the peripheral blood was evaluated. METHODS: Cohorts of
donor mice were treated with either progenipoietin-1, fetal liver tyrosine kinase-3 ligand,
granulocyte colony-stimulating factor, or a vehicle control. Hematopoietic progenitor/stem …
and fetal liver tyrosine kinase-3 receptors capable of inducing the proliferation of multiple
hematopoietic cell lineages. The potential of progenipoietin-1 to mobilize transplantable
hematopoietic stem cells into the peripheral blood was evaluated. METHODS: Cohorts of
donor mice were treated with either progenipoietin-1, fetal liver tyrosine kinase-3 ligand,
granulocyte colony-stimulating factor, or a vehicle control. Hematopoietic progenitor/stem …
