[HTML][HTML] Progenipoietins: biological characterization of a family of dual agonists of fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor
PR Streeter, NI Minster, LE Kahn, WF Hood… - Experimental …, 2001 - Elsevier
OBJECTIVE: The progenipoietins, a class of engineered proteins containing both fetal liver
tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were
functionally characterized in vitro and in vivo. MATERIALS AND METHODS: Four
representative progenipoietins were evaluated for receptor binding, receptor-dependent cell
proliferation, colony-forming unit activity, and their effects on hematopoiesis in the C57BL/6
mouse. RESULTS: The progenipoietins bound to fetal liver tyrosine kinase-3 and the …
tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were
functionally characterized in vitro and in vivo. MATERIALS AND METHODS: Four
representative progenipoietins were evaluated for receptor binding, receptor-dependent cell
proliferation, colony-forming unit activity, and their effects on hematopoiesis in the C57BL/6
mouse. RESULTS: The progenipoietins bound to fetal liver tyrosine kinase-3 and the …
