Endotoxin syndrome is a systemic inflammatory response mediated by inflammatory
cytokines. Nuclear factor κB (NF-κB) is the dominant regulator of the production of these
cytokines by inflammatory cells. The aim of this study was to assess the efficacy of in vivo
transfer of synthetic double-stranded oligodeoxynucleotides (ODN) with high affinity against
NF-κB (NF-κB/decoy/ODN) as a therapeutic strategy for treating endotoxin-induced fatal liver
injury. Liver injury was induced by administration of lipopolysaccharide (LPS) to …