The hereditary spastic paraplegias: nine genes and counting
JK Fink - Archives of neurology, 2003 - jamanetwork.com
The hereditary spastic paraplegias (HSPs) are inherited neurologic disorders in which the
primary symptom is insidiously progressive difficulty walking due to lower extremity
weakness and spasticity. There have been great strides in our knowledge of this group of
disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the
molecular causes of HSPs are beginning to emerge. This review summarizes these
advances in HSPs' genetics.
primary symptom is insidiously progressive difficulty walking due to lower extremity
weakness and spasticity. There have been great strides in our knowledge of this group of
disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the
molecular causes of HSPs are beginning to emerge. This review summarizes these
advances in HSPs' genetics.
