Effects of interferon and retinoic acid on the growth and differentiation of clonogenic leukemic cells from acute myelogenous leukemia patients treated with …
RE Gallagher, KJ Lurie, RD Leavitt, PH Wiernik - Leukemia research, 1987 - Elsevier
Studies with human myeloid leukemia cell lines indicate that combined interferon (INF) and
retinoic acid (RA) have greater effects in inhibiting cell growth and in inducing terminal
differentiation than either agent alone. Consequently, we studied the effects of these agents,
singly and in combination, on fresh leukemic blast cells obtained from 13 acute
myelogenous leukemia (AML) patients, most of whom were subsequently treated with
recombinant leukocyte-αA interferon (rINF-αA). The in-vitro response to rINF-αA and RA was …
retinoic acid (RA) have greater effects in inhibiting cell growth and in inducing terminal
differentiation than either agent alone. Consequently, we studied the effects of these agents,
singly and in combination, on fresh leukemic blast cells obtained from 13 acute
myelogenous leukemia (AML) patients, most of whom were subsequently treated with
recombinant leukocyte-αA interferon (rINF-αA). The in-vitro response to rINF-αA and RA was …