Long-term follow-up and potential for cure in acute promyelocytic leukaemia
MS Tallman, JM Rowe - Best Practice & Research Clinical Haematology, 2003 - Elsevier
Acute promyelocytic leukaemia (APL) may be characterized simultaneously as the most
potentially rapidly fatal human acute leukaemia if untreated, yet the most frequently cured
acute leukaemia if promptly diagnosed and treated without delay. Co-operative group and
single-institution studies which include large numbers of patients with relatively long follow-
up demonstrate that, with all-trans retinoic acid (ATRA) plus anthracycline-based
chemotherapy, the majority of newly-diagnosed patients appear cured of their disease. The …
potentially rapidly fatal human acute leukaemia if untreated, yet the most frequently cured
acute leukaemia if promptly diagnosed and treated without delay. Co-operative group and
single-institution studies which include large numbers of patients with relatively long follow-
up demonstrate that, with all-trans retinoic acid (ATRA) plus anthracycline-based
chemotherapy, the majority of newly-diagnosed patients appear cured of their disease. The …