A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses
FKM Chan, J Shisler, JG Bixby, M Felices… - Journal of Biological …, 2003 - ASBMB
Members of the tumor necrosis factor (TNF) receptor (TNFR) superfamily are potent
regulators of apoptosis, a process that is important for the maintenance of immune
homeostasis. Recent evidence suggests that TNFR-1 and Fas and TRAIL receptors can also
trigger an alternative form of cell death that is morphologically distinct from apoptosis.
Because distinct molecular components including the serine/threonine protein kinase
receptor-interacting protein (RIP) are required, we have referred to this alternative form of …
regulators of apoptosis, a process that is important for the maintenance of immune
homeostasis. Recent evidence suggests that TNFR-1 and Fas and TRAIL receptors can also
trigger an alternative form of cell death that is morphologically distinct from apoptosis.
Because distinct molecular components including the serine/threonine protein kinase
receptor-interacting protein (RIP) are required, we have referred to this alternative form of …
