High levels of human apolipoprotein AI and high density lipoproteins in transgenic mice do not enhance efflux of cholesterol from a depot of injected lipoproteins …
O Stein, Y Dabach, G Hollander, M Ben-Naim… - Atherosclerosis, 1999 - Elsevier
The role of high density lipoprotein (HDL) and apolipoprotein AI (apo AI) in promoting
cholesterol efflux from cultured cells and attenuation of development of atherosclerosis in
transgenic (tg) animals has been well documented. The aim of the present study was to
determine whether high levels of human (h) apo AI will enhance cholesterol removal in vivo.
h apo AI in sera of tg mice was 429±18 and 308±10 mg/dl in male and female mice, the ratio
of phospholipid (PL) to apo AI was 0.94 in tg and 2.4 and 1.9 in male and female controls …
cholesterol efflux from cultured cells and attenuation of development of atherosclerosis in
transgenic (tg) animals has been well documented. The aim of the present study was to
determine whether high levels of human (h) apo AI will enhance cholesterol removal in vivo.
h apo AI in sera of tg mice was 429±18 and 308±10 mg/dl in male and female mice, the ratio
of phospholipid (PL) to apo AI was 0.94 in tg and 2.4 and 1.9 in male and female controls …
