[HTML][HTML] The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS): peptidoglycan and lipoteichoic acid are inducers of DC …
KS Michelsen, A Aicher, M Mohaupt, T Hartung… - Journal of Biological …, 2001 - ASBMB
Toll-like receptors (TLRs) have been found to be key elements in pathogen recognition by
the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses
and initiation of acquired immunity. Here we focus on the potential involvement of TLR
ligand interaction in DC maturation. TLR2 knockout mice and mice carrying a TLR4 mutation
(C3H/HeJ) were investigated for DC maturation induced by peptidoglycan (PGN),
lipopolysaccharide (LPS), or lipoteichoic acids (LTAs). All stimuli induced maturation of …
the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses
and initiation of acquired immunity. Here we focus on the potential involvement of TLR
ligand interaction in DC maturation. TLR2 knockout mice and mice carrying a TLR4 mutation
(C3H/HeJ) were investigated for DC maturation induced by peptidoglycan (PGN),
lipopolysaccharide (LPS), or lipoteichoic acids (LTAs). All stimuli induced maturation of …
