[HTML][HTML] Transcriptional Glucose Signaling through The Glucose Response Element Is Mediated by the Pentose Phosphate Pathway (∗)
B Doiron, MH Cuif, R Chen, A Kahn - Journal of Biological Chemistry, 1996 - ASBMB
Glucose catabolism induces the expression of the L-type pyruvate kinase (L-PK) gene
through the glucose response element (GIRE). The metabolic pathway used by glucose after
its phosphorylation to glucose 6-phosphate by glucokinase to induce L-PK gene expression
in hepatocytes remains unknown. The sugar alcohol xylitol is metabolized to xylulose 5-
phosphate, an intermediate of the nonoxidative branch of the pentose phosphate pathway.
In this study, we demonstrated that xylitol at low concentration (O. 5 mM) induced the …
through the glucose response element (GIRE). The metabolic pathway used by glucose after
its phosphorylation to glucose 6-phosphate by glucokinase to induce L-PK gene expression
in hepatocytes remains unknown. The sugar alcohol xylitol is metabolized to xylulose 5-
phosphate, an intermediate of the nonoxidative branch of the pentose phosphate pathway.
In this study, we demonstrated that xylitol at low concentration (O. 5 mM) induced the …
