Kinases that associate with integrins are likely to mediate the assembly/disassembly of cell:
matrix junctions during cell migration. Here we show that ERK1 associates with α v β 3
integrin following the addition of platelet-derived growth factor to serum-starved Swiss or
NIH 3T3 fibroblasts in an interaction that is mediated by the central region of the β 3 integrin
cytodomain. α v β 3· ERK1 association occurred prior to focal complex formation and was
seen to initiate in small punctate complexes primarily in the peripheral regions of the plasma …