[HTML][HTML] Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1β and amyloid β42 peptide is potentiated by hypoxia in primary human neural …
Lipid messengers and amyloid beta (Aβ) peptides generated by cyclooxygenase-2 (COX-2)
and presenilin-1 (PS1) mediate pro-inflammatory signaling and neural degeneration in
Alzheimer's disease (AD) brain. This study provides data showing that theCOX-2 and PS1
genes each transcribe rare, highly labile RNA species that display early response gene
behavior in human neural (HN) cells in primary culture, down-regulation during human
neural development, and up-regulation in AD neocortex and hippocampal CA1. Together …
and presenilin-1 (PS1) mediate pro-inflammatory signaling and neural degeneration in
Alzheimer's disease (AD) brain. This study provides data showing that theCOX-2 and PS1
genes each transcribe rare, highly labile RNA species that display early response gene
behavior in human neural (HN) cells in primary culture, down-regulation during human
neural development, and up-regulation in AD neocortex and hippocampal CA1. Together …