Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and-nonpreferring lines of rats

MB Waller, JM Murphy, WJ McBride, L Lumeng… - Pharmacology …, 1986 - Elsevier
To determine if behavioral arousal may be associated with ethanol preference, the effects of
low to moderate doses of ethanol on spontaneous motor activity (SMA) were studied in the
selectively bred alcohol-preferring (P) and-nonpreferring (NP) lines of rats as well as in the
Maudsley Reactive (MR/N) and Nonreactive (MNR/N) strains. Alcohol-naive rats had food
and water available ad lib, but food was removed 24 hr before and during activity testing.
After an intraperitoneal injection of saline (5 ml) or ethanol (0.12 to 1.5 g/kg), SMA was …