[HTML][HTML] p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
MJ Rane, PY Coxon, DW Powell, R Webster… - Journal of Biological …, 2001 - ASBMB
Akt activation requires phosphorylation of Thr 308 and Ser 473 by 3-phosphoinositide-
dependent kinase-1 and 2 (PDK1 and PDK2), respectively. While PDK1 has been cloned
and sequenced, PDK2 has yet to be identified. The present study shows that
phosphatidylinositol 3-kinase-dependent p38 kinase activation regulates Akt
phosphorylation and activity in human neutrophils. Inhibition of p38 kinase activity with
SB203580 inhibited Akt Ser 473 phosphorylation following neutrophil stimulation with formyl …
dependent kinase-1 and 2 (PDK1 and PDK2), respectively. While PDK1 has been cloned
and sequenced, PDK2 has yet to be identified. The present study shows that
phosphatidylinositol 3-kinase-dependent p38 kinase activation regulates Akt
phosphorylation and activity in human neutrophils. Inhibition of p38 kinase activity with
SB203580 inhibited Akt Ser 473 phosphorylation following neutrophil stimulation with formyl …
