The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins
DA Parsell, S Lindquist - Annual review of genetics, 1993 - annualreviews.org
DA Parsell, S Lindquist
Annual review of genetics, 1993•annualreviews.orgOrganisms respond to sudden increases in temperature by synthesizing a small set of
proteins called the heat-shock proteins (hsps)(See Figure 1). This heat-shock response has
been highly conserved throughout evolution, not only as a physiological phenomenon, but
also at the level of the individual proteins. Hsps comprise some of the most highly conserved
protein families known. The level of amino-acid identity between all prokaryotic and
eukaryotic hsp70 proteins, for example, approaches 50%(95). Hsp families often include …
proteins called the heat-shock proteins (hsps)(See Figure 1). This heat-shock response has
been highly conserved throughout evolution, not only as a physiological phenomenon, but
also at the level of the individual proteins. Hsps comprise some of the most highly conserved
protein families known. The level of amino-acid identity between all prokaryotic and
eukaryotic hsp70 proteins, for example, approaches 50%(95). Hsp families often include …
Organisms respond to sudden increases in temperature by synthesizing a small set of proteins called the heat-shock proteins (hsps)(See Figure 1). This heat-shock response has been highly conserved throughout evolution, not only as a physiological phenomenon, but also at the level of the individual proteins. Hsps comprise some of the most highly conserved protein families known. The level of amino-acid identity between all prokaryotic and eukaryotic hsp70 proteins, for example, approaches 50%(95). Hsp families often include constitutive as well as heat-inducible c: P
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