[HTML][HTML] Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor …
J Lewis, A Devin, A Miller, Y Lin, Y Rodriguez… - Journal of Biological …, 2000 - ASBMB
The death domain kinase, receptor interacting protein (RIP), is one of the major components
of the tumor necrosis factor receptor 1 (TNFR1) complex and plays an essential role in tumor
necrosis factor (TNF)-mediated nuclear factor κB (NF-κB) activation. The activation of NF-κB
protects cells against TNF-induced apoptosis. Heat-shock proteins (Hsps) are chaperone
molecules that confer protein stability and help to restore protein native folding following
heat shock and other stresses. The most abundant Hsp, Hsp90, is also involved in …
of the tumor necrosis factor receptor 1 (TNFR1) complex and plays an essential role in tumor
necrosis factor (TNF)-mediated nuclear factor κB (NF-κB) activation. The activation of NF-κB
protects cells against TNF-induced apoptosis. Heat-shock proteins (Hsps) are chaperone
molecules that confer protein stability and help to restore protein native folding following
heat shock and other stresses. The most abundant Hsp, Hsp90, is also involved in …
