[HTML][HTML] BRCA1 augments transcription by the NF-κB transcription factor by binding to the Rel domain of the p65/RelA subunit
M Benezra, N Chevallier, DJ Morrison… - Journal of Biological …, 2003 - ASBMB
BRCA1 is a tumor suppressor gene mutated in cases of hereditary breast and ovarian
cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study,
we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-κB,
binds to the BRCA1 protein. Treatment of 293T cells with the cytokine tumor necrosis factor-
α induces an interaction between endogenous p65/RelA and BRCA1. GST-protein affinity
assay experiments reveal that the Rel homology domain of the p65/RelA subunit of NF-κB …
cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study,
we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-κB,
binds to the BRCA1 protein. Treatment of 293T cells with the cytokine tumor necrosis factor-
α induces an interaction between endogenous p65/RelA and BRCA1. GST-protein affinity
assay experiments reveal that the Rel homology domain of the p65/RelA subunit of NF-κB …
