Stabilization of p53 is a novel mechanism for proapoptotic function of NF-κB
S Fujioka, C Schmidt, GM Sclabas, Z Li… - Journal of Biological …, 2004 - ASBMB
Both pro-and antiapoptotic activities of NF-κB transcription factor have been observed;
however, less is known about the mechanism by which NF-κB induces apoptosis. To
elucidate how NF-κB regulates proapoptotic signaling, we performed functional analyses
using wild-type, ikk1-/-, ikk2-/-, rela-/-murine fibroblasts, MDAPanc-28/Puro, MDAPanc-
28/IκBαM, and HCT116/p53+/+ and HCT116/p53-/-cells with investigational anticancer
agent doxycycline as a superoxide inducer for generating apoptotic stimulus. In this report …
however, less is known about the mechanism by which NF-κB induces apoptosis. To
elucidate how NF-κB regulates proapoptotic signaling, we performed functional analyses
using wild-type, ikk1-/-, ikk2-/-, rela-/-murine fibroblasts, MDAPanc-28/Puro, MDAPanc-
28/IκBαM, and HCT116/p53+/+ and HCT116/p53-/-cells with investigational anticancer
agent doxycycline as a superoxide inducer for generating apoptotic stimulus. In this report …
