[HTML][HTML] Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
E Basso, L Fante, J Fowlkes, V Petronilli… - Journal of Biological …, 2005 - ASBMB
We have studied the properties of the permeability transition pore (PTP) in mitochondria
from the liver of mice where the Ppif gene encoding for mitochondrial Cyclophilin D (CyP-D)
had been inactivated. Mitochondria from Ppif–/–mice had no CyP-D and displayed a striking
desensitization of the PTP to Ca 2+, in that pore opening required about twice the Ca 2+
load necessary to open the pore in strain-matched, wild-type mitochondria. Mitochondria
lacking CyP-D were insensitive to Cyclosporin A (CsA), which increased the Ca 2+ retention …
from the liver of mice where the Ppif gene encoding for mitochondrial Cyclophilin D (CyP-D)
had been inactivated. Mitochondria from Ppif–/–mice had no CyP-D and displayed a striking
desensitization of the PTP to Ca 2+, in that pore opening required about twice the Ca 2+
load necessary to open the pore in strain-matched, wild-type mitochondria. Mitochondria
lacking CyP-D were insensitive to Cyclosporin A (CsA), which increased the Ca 2+ retention …