Image analysis of stage 1 melanoma (1.00–2.50 mm): lymphocytic infiltrates related to metastasis and survival
GC Pastorfide, AG Kibbi, AL De Roa… - Journal of cutaneous …, 1992 - Wiley Online Library
Journal of cutaneous pathology, 1992•Wiley Online Library
Image analysis of histologic sections of II patients with clinical Stage 1 melanoma, 1.00 mm–
2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic
infiltrates relative to metastasis and survival. An ago, sex, site, and thickness matched
control group of non‐metastasizing clinical Stage 1 melanoma revealed no significant
difference in the lymphocytic infiltrate parameters from the metastasizing group with the
exception of the ratio of lymphocyte infiltrate width lo the tumor width (p= 0.003). Increased …
2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic
infiltrates relative to metastasis and survival. An ago, sex, site, and thickness matched
control group of non‐metastasizing clinical Stage 1 melanoma revealed no significant
difference in the lymphocytic infiltrate parameters from the metastasizing group with the
exception of the ratio of lymphocyte infiltrate width lo the tumor width (p= 0.003). Increased …
Image analysis of histologic sections of II patients with clinical Stage 1 melanoma, 1.00 mm – 2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic infiltrates relative to metastasis and survival. An ago, sex, site, and thickness matched control group of non‐metastasizing clinical Stage 1 melanoma revealed no significant difference in the lymphocytic infiltrate parameters from the metastasizing group with the exception of the ratio of lymphocyte infiltrate width lo the tumor width (p = 0.003). Increased lymphocytic infiltrates within the tumor and subjacent lo its base significantly correlated with delayed lime to metastasis (p = 0.014 and p < 0.001, respectively) and longer survival period (p = 0.045 and p < 0.001, respectively). Lymphocytic infiltrate area at the tumor base in relation to tumor area was of prognostic value: the larger the ratio, the greater the time interval from metastasis to death (p = 0.008).
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