A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas
Using the polymerase chain reaction on human embryonic cDNAs, we isolated a cDNA
encoding a novel 504 amino acid protein, termed fibroblast growth factor receptor (FGFR)-5,
which is highly homologous to known FGFRs. The NH2-terminal portion of FGFR5 contains
a putative secretory signal sequence, three typical immunoglobulin-like domains, six
cysteines, and an acidic box, but no HAV motif. The COOH-terminal portion of FGFR5
contains one transmembrane domain but no intracellular kinase domain. Recombinant …
encoding a novel 504 amino acid protein, termed fibroblast growth factor receptor (FGFR)-5,
which is highly homologous to known FGFRs. The NH2-terminal portion of FGFR5 contains
a putative secretory signal sequence, three typical immunoglobulin-like domains, six
cysteines, and an acidic box, but no HAV motif. The COOH-terminal portion of FGFR5
contains one transmembrane domain but no intracellular kinase domain. Recombinant …
