The role of endothelial cells in the pathophysiology of sepsis has received increased
attention since the publication of studies showing that activated protein C can improve
survival in selected patients with sepsis. A recurring theme in sepsis research has been that
the endothelial cells can drive the inflammatory response by release of procoagulant and
proinflammatory molecules. It is now clear that there is “cross-talk” between the coagulation
and inflammatory cascades. Thus, prevention of endothelial injury and the resultant …