[HTML][HTML] Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR
N Abraham, DF Stojdl, PI Duncan, N Méthot… - Journal of Biological …, 1999 - ASBMB
The interferon-inducible, double-stranded RNA-dependent protein kinase PKR has been
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to
examine the requirement of PKR in these roles by targeted disruption at the amino terminal-
encoding region of the Pkr gene. By using a strategy that aims at disruption of the catalytic
domain of PKR, we have generated mice that are genetically ablated for functional PKR.
Similar to the other mouse model of Pkr disruption, we have observed no consequences of …
implicated in anti-viral, anti-tumor, and apoptotic responses. Others have attempted to
examine the requirement of PKR in these roles by targeted disruption at the amino terminal-
encoding region of the Pkr gene. By using a strategy that aims at disruption of the catalytic
domain of PKR, we have generated mice that are genetically ablated for functional PKR.
Similar to the other mouse model of Pkr disruption, we have observed no consequences of …