One of a family of extracellular matrix proteins, tenascin-C (TNC) is expressed in a
spatiotemporally restricted pattern associated with tissue remodeling during embryonic
development, wound healing, cancer invasion and tissue regeneration. Another form,
tenascin-X (TNX), is found in most tissues but most predominantly in heart and muscle, often
complementarily to TNC. The present analysis demonstrated their expression during early
heart development, using mouse lines containing the lacZ gene targeted to the TNC locus …