[HTML][HTML] Molecular cloning and characterization of human trabeculin-α, a giant protein defining a new family of actin-binding proteins
Y Sun, J Zhang, SK Kraeft, D Auclair, MS Chang… - Journal of Biological …, 1999 - ASBMB
We describe the molecular cloning and characterization of a novel giant human cytoplasmic
protein, trabeculin-α (M r= 614,000). Analysis of the deduced amino acid sequence reveals
homologies with several putative functional domains, including a pair of α-actinin-like actin
binding domains; regions of homology to plakins at either end of the giant polypeptide; 29
copies of a spectrin-like motif in the central region of the protein; two potential Ca 2+-binding
EF-hand motifs; and a Ser-rich region containing a repeated GSRX motif. With similarities to …
protein, trabeculin-α (M r= 614,000). Analysis of the deduced amino acid sequence reveals
homologies with several putative functional domains, including a pair of α-actinin-like actin
binding domains; regions of homology to plakins at either end of the giant polypeptide; 29
copies of a spectrin-like motif in the central region of the protein; two potential Ca 2+-binding
EF-hand motifs; and a Ser-rich region containing a repeated GSRX motif. With similarities to …
