[HTML][HTML] Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip−/− mice
KL Donnelly, MR Margosian, EJ Parks, SS Sheth… - The Journal of …, 2004 - Elsevier
The effect of decreased fatty acid oxidation on liver lipid metabolism in HcB-19 mice, a
mouse model of hyperlipidemia (Txnip−/−), was investigated using metabolic labeling. De
novo cholesterol synthesis and de novo lipogenesis were quantified using 1-13 C 1 acetic
acid, and liver triacylglycerol (TAG) derived from dietary fatty acids was quantified using
dietary glyceryl tri (hexandecanoate-d 31). Tissue samples were analyzed for TAG, free
cholesterol (FC), and cholesterol ester (CE) content. Txnip−/− mice had significantly …
mouse model of hyperlipidemia (Txnip−/−), was investigated using metabolic labeling. De
novo cholesterol synthesis and de novo lipogenesis were quantified using 1-13 C 1 acetic
acid, and liver triacylglycerol (TAG) derived from dietary fatty acids was quantified using
dietary glyceryl tri (hexandecanoate-d 31). Tissue samples were analyzed for TAG, free
cholesterol (FC), and cholesterol ester (CE) content. Txnip−/− mice had significantly …
